Meld 3.0 Calculator

MELD 3.0 Score Calculator

Your MELD 3.0 Score: –

function calculateMELD30() { var bilirubin = parseFloat(document.getElementById('bilirubin').value); var creatinine = parseFloat(document.getElementById('creatinine').value); var inr = parseFloat(document.getElementById('inr').value); var sodium = parseFloat(document.getElementById('sodium').value); var albumin = parseFloat(document.getElementById('albumin').value); var onDialysis = document.getElementById('onDialysis').checked; var sex = document.getElementById('sexMale').checked ? 'Male' : 'Female'; if (isNaN(bilirubin) || isNaN(creatinine) || isNaN(inr) || isNaN(sodium) || isNaN(albumin)) { document.getElementById('meld30Result').innerHTML = 'Please enter valid numbers for all fields.'; return; } // Apply caps and floors for MELD 3.0 calculation var adjBilirubin = Math.max(1.0, bilirubin); var adjCreatinine; if (onDialysis) { adjCreatinine = 4.0; // If on dialysis, creatinine is capped at 4.0 } else { adjCreatinine = Math.min(4.0, Math.max(1.0, creatinine)); // Capped at 4.0, floored at 1.0 } var adjINR = Math.max(1.0, inr); // Floored at 1.0 var adjSodium = Math.min(137, Math.max(125, sodium)); // Capped at 137, floored at 125 var adjAlbumin = Math.min(3.5, Math.max(1.0, albumin)); // Capped at 3.5, floored at 1.0 var sexFactor = (sex === 'Female') ? 1 : 0; // MELD 3.0 Formula // MELD 3.0 = 1.33 * (0.95 * ln(Bilirubin) + 0.54 * ln(Creatinine) + 0.94 * ln(INR) + 0.31 * (137 – Sodium) + 0.54 * (3.5 – Albumin) + 0.34 * (if female, 1 else 0) + 0.63) var meld30Score = 1.33 * ( 0.95 * Math.log(adjBilirubin) + 0.54 * Math.log(adjCreatinine) + 0.94 * Math.log(adjINR) + 0.31 * (137 – adjSodium) + 0.54 * (3.5 – adjAlbumin) + 0.34 * sexFactor + 0.63 ); meld30Score = Math.round(meld30Score); // Round to the nearest whole number document.getElementById('meld30Result').innerHTML = 'Your MELD 3.0 Score: ' + meld30Score + ''; }

Understanding the MELD 3.0 Score

The Model for End-Stage Liver Disease (MELD) score is a widely used prognostic tool that assesses the severity of chronic liver disease. It helps predict short-term mortality in patients with advanced liver disease and is crucial for prioritizing patients for liver transplantation.

The MELD 3.0 score is an updated version of the original MELD and MELD-Na scores, designed to provide a more accurate assessment of disease severity and improve fairness in organ allocation. It incorporates several key laboratory values and patient characteristics:

• Total Bilirubin: A measure of liver's ability to process waste. Higher levels indicate poorer liver function.
• Creatinine: An indicator of kidney function, which can be impaired in advanced liver disease (hepatorenal syndrome).
• INR (International Normalized Ratio): Measures the time it takes for blood to clot, reflecting the liver's ability to produce clotting factors. Higher INR indicates more severe liver dysfunction.
• Sodium: Serum sodium levels are included as hyponatremia (low sodium) is common in advanced liver disease and is associated with increased mortality.
• Albumin: A protein produced by the liver. Lower albumin levels can indicate reduced liver synthetic function.
• Sex: Patient's biological sex is included as a factor to account for physiological differences that may impact outcomes.
• Dialysis Status: Patients on dialysis have their creatinine level capped at 4.0 mg/dL, reflecting severe kidney impairment.

How the MELD 3.0 Score is Used

A higher MELD 3.0 score indicates more severe liver disease and a higher risk of mortality. In many regions, particularly in the United States, the MELD score (including MELD 3.0) is a primary factor in determining a patient's priority on the liver transplant waiting list. The goal is to allocate organs to those who are sickest and most likely to benefit from a transplant.

Interpreting Your Score

The MELD 3.0 score typically ranges from 6 to 40. While a higher score signifies greater disease severity, it's important to remember that this calculator provides an estimate based on the provided inputs. The interpretation of the score and its implications for treatment and prognosis should always be discussed with a qualified healthcare professional.

Example Calculation:

Let's consider a Male patient, not on dialysis, with the following lab values:

• Total Bilirubin: 2.5 mg/dL
• Creatinine: 1.8 mg/dL
• INR: 1.6
• Sodium: 130 mEq/L
• Albumin: 2.8 g/dL

Using the MELD 3.0 formula with these values, the calculated score would be approximately 20. This score would place the patient in a moderate to high severity category, indicating significant liver dysfunction.

Disclaimer: This MELD 3.0 calculator is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult with a healthcare provider for any health concerns or before making any decisions related to your health or treatment.