Understanding Semaglutide Reconstitution and Dosage
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for managing type 2 diabetes and chronic weight management. It is often supplied as a lyophilized (freeze-dried) powder in a vial, which requires reconstitution with a sterile diluent, typically bacteriostatic water, before administration.
Accurate reconstitution and dosage calculation are critical for patient safety and treatment efficacy. This calculator helps you determine the correct concentration of your reconstituted semaglutide and the precise volume (in International Units, IU, for an insulin syringe) to draw for your desired dose.
How to Use the Semaglutide Calculator:
Peptide Vial Size (mg): Enter the total amount of semaglutide powder in your vial, usually specified in milligrams (mg). Common sizes include 2mg, 5mg, or 10mg.
Bacteriostatic Water Volume (ml): Input the volume of bacteriostatic water (or other sterile diluent) you plan to add to the vial for reconstitution, in milliliters (ml). Common volumes are 1ml, 2ml, or 3ml.
Desired Single Dose (mg): Enter the specific dose of semaglutide you intend to administer per injection, in milligrams (mg). Doses vary based on treatment protocol and individual needs, often starting lower and titrating up (e.g., 0.25mg, 0.5mg, 1.0mg, 1.7mg, 2.4mg).
Syringe Capacity (IU): Specify the total capacity of the insulin syringe you are using, in International Units (IU). A standard 1ml insulin syringe typically has a capacity of 100 IU. This is crucial for converting the liquid volume into syringe markings.
Understanding the Results:
Concentration (mg/ml): This tells you how many milligrams of semaglutide are in each milliliter of your reconstituted solution.
Concentration (mcg/ml): This is the same concentration but expressed in micrograms per milliliter, which is often easier to work with for smaller doses. (1 mg = 1000 mcg).
IU to Draw for Desired Dose: This is the most critical result. It tells you exactly how many International Units (IU) you need to draw into your insulin syringe to get your desired single dose.
Total Desired Doses in Vial: This indicates how many of your desired single doses can be obtained from the entire reconstituted vial.
Important Considerations:
Always use sterile technique when reconstituting peptides.
Ensure you are using bacteriostatic water for reconstitution, not plain sterile water, to inhibit bacterial growth over time.
Store reconstituted semaglutide according to manufacturer guidelines, typically refrigerated, and note its expiration after reconstitution.
This calculator is for informational purposes only and should not replace professional medical advice. Always consult with a healthcare provider for proper dosage and administration instructions.
Double-check all input values against your product's specifications and your prescription.
Example Calculation:
Let's say you have a 5mg vial of Semaglutide and you reconstitute it with 2ml of Bacteriostatic Water. Your doctor has prescribed a starting dose of 0.25mg per week, and you are using a standard 100 IU (1ml) insulin syringe.
Using the calculator:
Peptide Vial Size (mg): 5
Bacteriostatic Water Volume (ml): 2
Desired Single Dose (mg): 0.25
Syringe Capacity (IU): 100
The calculator would yield:
Concentration (mg/ml): 2.5 mg/ml
Concentration (mcg/ml): 2500 mcg/ml
IU to Draw for Desired Dose: 10 IU
Total Desired Doses in Vial: 20 doses
This means you would draw to the 10 IU mark on your 100 IU insulin syringe to get a 0.25mg dose of Semaglutide, and the vial would last for 20 such doses.
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function calculateSemaglutideDose() {
// Get input values
var peptideVialSizeMg = parseFloat(document.getElementById("peptideVialSizeMg").value);
var bacWaterVolumeMl = parseFloat(document.getElementById("bacWaterVolumeMl").value);
var desiredDoseMg = parseFloat(document.getElementById("desiredDoseMg").value);
var syringeCapacityIU = parseFloat(document.getElementById("syringeCapacityIU").value);
var resultDiv = document.getElementById("semaglutideResult");
resultDiv.innerHTML = ""; // Clear previous results
// Validate inputs
if (isNaN(peptideVialSizeMg) || peptideVialSizeMg <= 0) {
resultDiv.innerHTML = "Please enter a valid Peptide Vial Size (mg).";
return;
}
if (isNaN(bacWaterVolumeMl) || bacWaterVolumeMl <= 0) {
resultDiv.innerHTML = "Please enter a valid Bacteriostatic Water Volume (ml).";
return;
}
if (isNaN(desiredDoseMg) || desiredDoseMg <= 0) {
resultDiv.innerHTML = "Please enter a valid Desired Single Dose (mg).";
return;
}
if (isNaN(syringeCapacityIU) || syringeCapacityIU <= 0) {
resultDiv.innerHTML = "Please enter a valid Syringe Capacity (IU).";
return;
}
// Calculations
var concentrationMgMl = peptideVialSizeMg / bacWaterVolumeMl;
var concentrationMcgMl = concentrationMgMl * 1000; // 1 mg = 1000 mcg
// Assuming syringeCapacityIU represents the IU for 1ml (e.g., 100 IU for a 1ml syringe)
// So, mcg per IU = concentrationMcgMl / syringeCapacityIU
var mcgPerIU = concentrationMcgMl / syringeCapacityIU;
var desiredDoseMcg = desiredDoseMg * 1000;
var iuToDraw = desiredDoseMcg / mcgPerIU;
var totalMgInVial = peptideVialSizeMg;
var totalDoses = totalMgInVial / desiredDoseMg;
// Display results
resultDiv.innerHTML += "Concentration: " + concentrationMgMl.toFixed(2) + " mg/ml";
resultDiv.innerHTML += "Concentration: " + concentrationMcgMl.toFixed(0) + " mcg/ml";
resultDiv.innerHTML += "IU to Draw for Desired Dose (" + desiredDoseMg.toFixed(2) + " mg): " + iuToDraw.toFixed(1) + " IU";
resultDiv.innerHTML += "Total Desired Doses in Vial: " + Math.floor(totalDoses) + " doses";
resultDiv.innerHTML += "(Note: IU to draw is rounded to one decimal place for practical syringe measurement.)";
}